**Core Concept**
Edward Jenner was a pioneering British physician and scientist who is recognized as the developer of the smallpox vaccine. He is considered one of the most important figures in the history of medicine, and his work laid the foundation for the development of vaccines against other diseases.

**Why the Correct Answer is Right**
Edward Jenner was born in 1749 and passed away on January 26, 1823, at the age of 73. He died in Berkeley, Gloucestershire, England. His death occurred more than a century after his groundbreaking discovery of the smallpox vaccine, which he administered to James Phipps, the eight-year-old son of his gardener, on May 14, 1796.

**Why Each Wrong Option is Incorrect**
**Option A:** 1749 is the year of Edward Jenner's birth, not his death.
**Option B:** 1775 is not a year associated with Edward Jenner's life or death.
**Option D:** 1920 is more than 90 years after Edward Jenner's death, and there is no connection between this year and the life of Edward Jenner.

**Clinical Pearl / High-Yield Fact**
Edward Jenner's work on the smallpox vaccine is a testament to the power of scientific inquiry and the importance of vaccination in preventing infectious diseases. His discovery has saved countless lives and continues to shape public health policy to this day.

**✓ Correct Answer: C. 1823**