**Core Concept**
The diagnosis and management of a solitary liver lesion require a combination of imaging techniques to determine its nature, size, and potential impact on liver function. Hepatic scintigraphy, also known as liver scan or hepatobiliary scintigraphy, uses radioactive tracers to evaluate liver function and detect abnormalities.

**Why the Correct Answer is Right**
Hepatic scintigraphy is a non-invasive test that can help differentiate between benign and malignant liver lesions. It is particularly useful for evaluating lesions that are not easily distinguishable on ultrasound or CT scans. The radioactive tracer is taken up by the liver cells and eliminated through the bile, allowing for the visualization of the biliary system and the detection of any blockages or abnormalities. This test is especially useful for evaluating the functional integrity of the liver and detecting lesions such as focal nodular hyperplasia (FNH) or hepatocellular adenoma.

**Why Each Wrong Option is Incorrect**
**Option A:** Ultrasound-guided biopsy of the lesion is not the next best step because it is an invasive procedure that carries a risk of bleeding and infection. Unless the diagnosis is highly suggestive of a specific type of lesion, such as a hepatocellular carcinoma, biopsy should be avoided until non-invasive tests have been performed.

**Option C:** Hepatic angiography is a more invasive test that involves injecting a contrast agent into the hepatic artery to visualize the blood vessels of the liver. While it can be useful for detecting vascular abnormalities, it is not typically the next step in evaluating a solitary liver lesion.

**Option D:** Contrast-enhanced CT scan of the liver can provide detailed information about the size, location, and characteristics of the liver lesion. However, it may not be able to distinguish between benign and malignant lesions, and it may not be as sensitive as hepatic scintigraphy for detecting certain types of lesions.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the choice of imaging test depends on the clinical context and the results of previous tests. A combination of imaging techniques, including ultrasound, CT, and scintigraphy, may be necessary to evaluate a solitary liver lesion accurately.

**✓ Correct Answer: B. Hepatic scintigraphy**