**Core Concept**
Hepatic scintigraphy is a diagnostic imaging technique that uses radioactive tracers to visualize the liver's blood flow, function, and structure. It is particularly useful for characterizing liver lesions and assessing liver function.

**Why the Correct Answer is Right**
Hepatic scintigraphy is the next best step in the evaluation of a solitary liver lesion because it can differentiate between benign and malignant lesions based on their blood flow characteristics. The radioactive tracer, such as technetium-99m sulfur colloid, is taken up by normal liver cells and excreted into the bile, allowing for the identification of normal liver tissue. This helps in identifying the nature of the lesion, whether it is a simple cyst, hemangioma, or a more sinister lesion like hepatocellular carcinoma. Additionally, hepatic scintigraphy can assess liver function and detect any abnormalities in liver perfusion.

**Why Each Wrong Option is Incorrect**
**Option A:** Ultrasound-guided biopsy may be considered if the lesion is large and easily accessible, but it carries a risk of bleeding and tumor seeding, especially if the lesion is malignant.
**Option C:** Hepatic angiography is typically reserved for preoperative planning or in cases where a vascular intervention is required. It is not the initial step in evaluating a solitary liver lesion.
**Option D:** Contrast-enhanced CT scan of the liver is a valuable diagnostic tool, but it may not provide the functional information that hepatic scintigraphy offers. CT scan may also expose the patient to radiation.

**Clinical Pearl / High-Yield Fact**
When evaluating a liver lesion, it is essential to consider the patient's age, risk factors for liver disease, and the characteristics of the lesion on imaging studies. Hepatic scintigraphy can provide valuable information about liver function and blood flow, which can guide further management.

**✓ Correct Answer: B. Hepatic scintigraphy**