Earliest feature of reversible cell injury is:
**Core Concept**
Cell injury in reversible cell injury is characterized by alterations in cellular homeostasis, leading to changes in cellular morphology and function. This process is often associated with disturbances in energy production, particularly in the mitochondria.
**Why the Correct Answer is Right**
The earliest feature of reversible cell injury is the accumulation of glycogen and lipids in the rough endoplasmic reticulum (RER). This is due to the inhibition of glycogenolysis and lipolysis, resulting in an accumulation of these substances within the cell. Additionally, the cell's ability to maintain cellular homeostasis is compromised, leading to changes in the distribution of organelles and the formation of microvilli.
**Why Each Wrong Option is Incorrect**
**Option A:** Swelling of the mitochondria is a feature of irreversible cell injury, not reversible cell injury.
**Option B:** Disruption of the plasma membrane is a feature of irreversible cell injury, not reversible cell injury.
**Option C:** This option is not a recognized feature of reversible cell injury.
**Clinical Pearl / High-Yield Fact**
Reversible cell injury can progress to irreversible cell injury if the underlying cause is not addressed. Early recognition of reversible cell injury is crucial in preventing further damage and promoting recovery.
**Correct Answer:** C. Accumulation of glycogen and lipids in the rough endoplasmic reticulum.