E6, E7 genes of which virus are implicated in oncogenesis –
**Core Concept**
The E6 and E7 genes of human papillomavirus (HPV) are involved in the process of oncogenesis, particularly in the development of cervical cancer. These genes encode for proteins that disrupt normal cell cycle regulation, leading to uncontrolled cell growth and tumor formation.
**Why the Correct Answer is Right**
The E6 protein of HPV interferes with the function of the tumor suppressor protein p53, which normally helps to repair DNA damage or induce apoptosis in damaged cells. By binding to p53, E6 promotes the degradation of p53, allowing damaged cells to continue to proliferate. The E7 protein, on the other hand, binds to and inactivates the retinoblastoma protein (Rb), which normally regulates the transition from the G1 to the S phase of the cell cycle. By inactivating Rb, E7 allows cells to bypass normal cell cycle checkpoints and continue to proliferate.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because HPV is not associated with the development of liver cancer.
* **Option B:** This option is incorrect because the E6 and E7 genes of HPV are not implicated in the development of skin cancer, although HPV is associated with some types of skin cancer.
* **Option C:** This option is incorrect because the E6 and E7 genes of HPV are not associated with the development of colon cancer.
**Clinical Pearl / High-Yield Fact**
HPV infection is a major risk factor for cervical cancer, and vaccination against HPV can help to prevent this disease. The E6 and E7 genes of HPV are also implicated in the development of other cancers, including oropharyngeal cancer and anal cancer.
**Correct Answer:** A. HPV.