E cadherin gene deficiency is seen in:
Correct Answer: Gastric cancer
Description: Cadherin is derived from the “calcium-dependent adherence protein.” It participates in interactions between cells of the same type. The linkage of cadherins with the cytoskeleton occurs through the catenins.
The cell-to-cell interactions mediated by cadherin and catenins play a major role in regulating cell motility, proliferation, and differentiation and account for the inhibition of cell proliferation that occurs when cultured normal cells contact each other (“contact inhibition”).
Reduced function of E-cadherin is associated with certain types of breast and gastric cancer. Mutation and altered expression of the Wnt/β-catenin pathway are implicated in gastrointestinal and liver cancer development.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now