**Core Concept**
Tardive dyskinesia is a type of movement disorder characterized by repetitive, involuntary movements of the face, trunk, and limbs, often as a side effect of long-term treatment with antipsychotic medications. This condition is associated with dopamine receptor blockade, particularly D2 receptor antagonism.

**Why the Correct Answer is Right**
The risk of developing tardive dyskinesia is influenced by the type of antipsychotic medication used. **First-generation antipsychotics** (also known as typical antipsychotics), which primarily block D2 receptors, have a higher risk of causing tardive dyskinesia compared to **second-generation antipsychotics** (atypical antipsychotics), which have a lower affinity for D2 receptors and a higher affinity for serotonin 5-HT2A receptors. This is because atypical antipsychotics tend to have a more balanced receptor profile, which reduces the risk of dopamine receptor blockade.

**Why Each Wrong Option is Incorrect**
**Option A:** First-generation antipsychotics are actually associated with a higher risk of tardive dyskinesia.
**Option B:** Dopamine receptor agonists, such as pramipexole, can actually exacerbate tardive dyskinesia.
**Option C:** Second-generation antipsychotics are not entirely devoid of risk, but they are generally considered to have a lower risk profile compared to first-generation antipsychotics.

**Clinical Pearl / High-Yield Fact**
When treating patients with antipsychotic medications, it is essential to monitor for signs of tardive dyskinesia, particularly in vulnerable populations such as the elderly and those with a history of movement disorders.

**Correct Answer:** C. Second-generation antipsychotics.