True about shigella dysentriae except –
**Core Concept**
Shigella dysenteriae is a gram-negative, facultative anaerobic bacterium that causes shigellosis, a type of dysentery characterized by diarrhea, abdominal pain, and fever. This pathogen is notorious for producing Shiga toxin, which plays a crucial role in its virulence.
**Why the Correct Answer is Right**
Shigella dysenteriae serotype 1 is the most virulent strain and is responsible for producing the Shiga toxin, which is encoded by the bacteriophage SfX. The Shiga toxin causes damage to the intestinal epithelial cells, leading to inflammation, hemorrhage, and fluid loss. The toxin inhibits protein synthesis by cleaving the 28S rRNA in the 60S ribosomal subunit, resulting in cell death and tissue damage.
**Why Each Wrong Option is Incorrect**
**Option A:**
Shigella dysenteriae is a gram-negative bacterium, but this option is not relevant to the question, as the question is about the characteristics of Shigella dysenteriae, not its gram staining properties.
**Option B:**
Shigella dysenteriae produces enterotoxins, but it is the Shiga toxin that is most closely associated with its virulence and pathogenesis.
**Option C:**
Shigella dysenteriae is transmitted through fecal-oral contact, but this option is not the correct answer, as the question is asking for an exception to a characteristic of Shigella dysenteriae.
**Option D:**
Shigella dysenteriae is susceptible to ciprofloxacin, but this option is not relevant to the question, as the question is about the characteristics of Shigella dysenteriae, not its antibiotic susceptibility.
**Clinical Pearl / High-Yield Fact**
Shigella dysenteriae is a classic example of a bacterium that can cause severe dysentery, and its Shiga toxin is a key virulence factor. The toxin's mechanism of action, which involves the cleavage of 28S rRNA, is a critical aspect of its pathogenesis.
**Correct Answer: C. Shigella dysenteriae is transmitted through fecal-oral contact.**