**Core Concept**
The patient's presentation of a large recurrent duodenal ulcer requires a treatment approach that balances the need for effective ulcer healing with the risk of complications, such as bleeding or perforation. The procedure of choice should aim to eradicate Helicobacter pylori infection, reduce acid production, and promote ulcer healing.

**Why the Correct Answer is Right**
The recommended procedure for managing large recurrent duodenal ulcers is laparoscopic truncal vagotomy with pyloroplasty. This surgical approach involves cutting the vagus nerve to reduce gastric acid production, while also creating a pyloroplasty to ensure adequate gastric emptying. This combination of procedures effectively reduces acid production and promotes ulcer healing, making it an ideal choice for managing large recurrent duodenal ulcers.

**Why Each Wrong Option is Incorrect**
* **Option A:** Gastric acid suppression with proton pump inhibitors (PPIs) alone may not be sufficient to manage large recurrent duodenal ulcers, as it does not address the underlying cause of the ulcer (Helicobacter pylori infection) or reduce acid production.
* **Option B:** Laparoscopic pyloroplasty alone may not be effective in managing large recurrent duodenal ulcers, as it does not address the underlying cause of the ulcer or reduce acid production.
* **Option C:** Laparoscopic antrectomy may be an option for managing large recurrent duodenal ulcers, but it is not the procedure of choice due to its associated risks and complications.

**Clinical Pearl / High-Yield Fact**
When managing large recurrent duodenal ulcers, it is essential to address the underlying cause of the ulcer, which is often Helicobacter pylori infection. Eradication of the infection should be a priority in the treatment plan.

**Correct Answer:** C.