**Core Concept**
The question tests the understanding of **drug dependence**, which is a state of adaptation that is manifested by a drug class-specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, or administering an antagonist. **Physical dependence** and **psychological dependence** are two key aspects of drug dependence.

**Why the Correct Answer is Right**
Drugs that cause both physical and psychological dependence typically affect the **central nervous system (CNS)** and have a high potential for abuse. These include **opioids**, **stimulants**, and certain **sedatives**. They work by activating the brain's **reward pathway**, releasing **dopamine**, and creating a feeling of euphoria, which leads to psychological dependence. Simultaneously, they can lead to physical dependence through **neuroadaptation**, where the body adapts to the constant presence of the drug, leading to withdrawal symptoms when the drug is stopped.

**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because while some drugs may cause psychological dependence, they may not necessarily lead to physical dependence.
**Option B:** Incorrect as it may not encompass the full range of drugs that cause both types of dependence.
**Option C:** Incorrect because it is too narrow, focusing only on drugs that may cause physical dependence without considering psychological aspects.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that drugs with a high potential for both physical and psychological dependence are often regulated and monitored closely due to their abuse potential. **Opioids** are a classic example, given their significant role in the current **opioid epidemic**.

**Correct Answer:** D. Opioids.