**Core Concept**
In neutropenic patients, the increased risk of infections necessitates the use of antimicrobial agents that can effectively target a broad range of pathogens. This requires careful consideration of the pharmacokinetics and pharmacodynamics of various antibiotics, as well as their potential toxicity and interactions.

**Why the Correct Answer is Right**
The correct answer involves the use of aminoglycosides, which are bactericidal antibiotics that can effectively target gram-negative bacteria. Aminoglycosides work by inhibiting protein synthesis through binding to the 30S ribosomal subunit, ultimately leading to the death of the bacterial cell. They are particularly useful in neutropenic patients due to their ability to penetrate into tissues and reach high concentrations in areas such as the lungs and urinary tract.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not mention aminoglycosides, which are a critical component of antimicrobial therapy in neutropenic patients.
**Option B:** This option is incorrect because it suggests the use of only one type of antibiotic, whereas a combination of antibiotics is often necessary to effectively cover a broad range of pathogens in neutropenic patients.
**Option C:** This option is incorrect because it implies that the use of antibiotics in neutropenic patients is solely based on the type of infection present, whereas the underlying immune status of the patient must also be taken into account.

**Clinical Pearl / High-Yield Fact**
In neutropenic patients, the use of aminoglycosides should be carefully monitored due to the potential risk of nephrotoxicity and ototoxicity. This can be mitigated by monitoring serum creatinine levels and performing regular audiograms.

**Correct Answer:** C.