Drugs to be avoided in G6PD deficiency is ?
**Core Concept**
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that affects the enzyme responsible for protecting red blood cells from oxidative damage. Individuals with G6PD deficiency are more susceptible to hemolysis (red blood cell destruction) when exposed to certain medications or substances.
**Why the Correct Answer is Right**
Drugs that are oxidizing agents or induce oxidative stress can trigger hemolysis in individuals with G6PD deficiency. Primaquine, an antimalarial medication, is a classic example of a drug that should be avoided in patients with G6PD deficiency. It works by inducing oxidative stress in the red blood cells, leading to their destruction. Other oxidizing agents, such as certain antibiotics (e.g., chloramphenicol, sulfonamides) and antimalarial medications (e.g., pamaquine, atovaquone), should also be avoided.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect as there is no information provided to suggest that this medication is an oxidizing agent or induces oxidative stress.
* **Option B:** This option is incorrect as there is no information provided to suggest that this medication is contraindicated in G6PD deficiency.
* **Option C:** This option is incorrect as there is no information provided to suggest that this medication is an oxidizing agent or induces oxidative stress.
**Clinical Pearl / High-Yield Fact**
Individuals with G6PD deficiency should avoid any medications that can induce oxidative stress, including certain antimalarial medications, antibiotics, and other oxidizing agents. A thorough medical history and laboratory tests can help identify individuals at risk and guide appropriate medication selection.
**Correct Answer:** C.