Drugs to be avoided in G6PD deficiency is –
**Core Concept**
G6PD deficiency is a genetic disorder that affects the enzyme glucose-6-phosphate dehydrogenase, leading to the breakdown of red blood cells (hemolysis) when exposed to certain oxidizing agents. This condition requires careful management of medications to prevent hemolytic episodes.
**Why the Correct Answer is Right**
Drugs that generate reactive oxygen species (ROS) or act as oxidizing agents can exacerbate hemolysis in G6PD deficiency. Primaquine, an antimalarial drug, is a classic example of such a medication. It induces the production of ROS, which can lead to the breakdown of red blood cells in individuals with G6PD deficiency. Other medications that can cause hemolysis in G6PD deficiency include sulfonamides (e.g., sulfadiazine, sulfamethoxazole), antimalarials (e.g., chloroquine), and certain antibiotics (e.g., nitrofurantoin).
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specify a medication that is contraindicated in G6PD deficiency.
* **Option B:** This option is incorrect because it does not provide a clear example of a medication that can cause hemolysis in G6PD deficiency.
* **Option C:** This option is incorrect because it does not specify a medication that is contraindicated in G6PD deficiency.
**Clinical Pearl / High-Yield Fact**
When prescribing medications to patients with G6PD deficiency, it is essential to consider the potential for hemolysis. Patients may be asymptomatic between episodes, so a thorough medical history and medication review are crucial in preventing hemolytic crises.
**Correct Answer: C. Primaquine.**