Drugs that can enhance action of sulfonylurea include the following, except:
Correct Answer: Diazoxide
Description: Drugs that enhance SU action (may precipitate hypoglycaemia) are-
(a) Displace from protein binding: Phenylbutazone, sulfinpyrazone, salicylates, sulfonamides.
(b) Inhibit metabolism/excretion: Cimetidine, ketoconazole, sulfonamides, warfarin, chloramphenicol, acute alcohol intake (also synergises by causing hypoglycaemia).
(c) Synergise with or prolong pharmacodynamic action: Salicylates, propranolol (cardioselective antihypertensives, lithium, theophylline, alcohol (by inhibiting gluconeogenesis).
Minoxidil and diazoxide are K+ channel openers, which were used earlier in severe hypertension and hypertensive emergencies.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 296
Category:
Pharmacology
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