**Core Concept**
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against various cellular components. Certain drugs can trigger or exacerbate SLE by inducing the production of these autoantibodies, leading to a clinical presentation similar to idiopathic SLE.

**Why the Correct Answer is Right**
The correct answer involves drugs that are known to cause drug-induced lupus erythematosus (DILE). These drugs work by various mechanisms, including the formation of drug-protein adducts, which can mimic the activity of endogenous proteins and trigger an immune response. For example, hydralazine and procainamide are known to cause DILE by forming covalent bonds with proteins, leading to the production of autoantibodies against histones and other nuclear components.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a known cause of SLE. While some medications may have a rare association with SLE, this option is not a well-documented case.
**Option B:** This option is not a known cause of SLE. In fact, this medication is sometimes used to treat autoimmune disorders, including lupus.
**Option C:** This option is a known cause of DILE, but it is not the most common or well-documented case.

**Clinical Pearl / High-Yield Fact**
Remember that DILE can present with symptoms similar to idiopathic SLE, including joint pain, fever, and skin rash. However, DILE typically resolves within weeks to months after discontinuation of the offending medication.

**Correct Answer: C. Penicillamine