Drug which can act as antagonis of Haloperidole ?
**Core Concept**
Haloperidol is a typical antipsychotic medication that acts as a dopamine D2 receptor antagonist. It is primarily used to treat schizophrenia and acute psychosis. The question is asking for a drug that can counteract or reverse the effects of haloperidol.
**Why the Correct Answer is Right**
Haloperidol's effects can be reversed by drugs that act as dopamine D2 receptor agonists or by drugs that block the dopamine D2 receptor. One such drug is **Metoclopramide**, which is a dopamine D2 receptor antagonist at high doses and a dopamine D2 receptor agonist at low doses. Metoclopramide's agonist activity can counteract the effects of haloperidol, making it a useful antidote in certain situations.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specify a drug that can counteract haloperidol's effects.
* **Option B:** This option is incorrect because it is not a well-known antidote for haloperidol.
* **Option D:** This option is incorrect because it is not a dopamine D2 receptor agonist and therefore cannot counteract haloperidol's effects.
**Clinical Pearl / High-Yield Fact**
Metoclopramide's antidotal effects on haloperidol can be useful in managing extrapyramidal side effects (EPS), such as dystonia and parkinsonism, which are common side effects of typical antipsychotics like haloperidol.
**Correct Answer:** C. Metoclopramide