**Core Concept**
Post-operative shivering is a common complication after general anesthesia, resulting from changes in body temperature regulation, stress response, and altered hypothalamic function. The ideal treatment should target the underlying pathophysiology to effectively manage this condition.

**Why the Correct Answer is Right**
The correct answer is **Clonidine**. Clonidine is an alpha-2 adrenergic agonist that helps to decrease the body's stress response and sympathetic activity, which are contributing factors to post-operative shivering. By reducing the release of norepinephrine, clonidine can help to stabilize body temperature and alleviate shivering. This is because the hypothalamus is less sensitive to cold stress, which can help to reduce the severity of shivering.

**Why Each Wrong Option is Incorrect**
**Option A:** **Doxapram** is actually used to treat respiratory depression and is not a first-line treatment for post-operative shivering.
**Option B:** **Naloxone** is an opioid antagonist used to reverse opioid overdose and is not effective in treating post-operative shivering.
**Option C:** **Dantrolene** is a muscle relaxant used to treat malignant hyperthermia, but it's not the primary treatment for post-operative shivering.

**Clinical Pearl / High-Yield Fact**
Remember that post-operative shivering can be a sign of underlying issues such as hypothermia, hypoxia, or anesthetic agents. Always assess the patient's overall condition and consider the underlying cause before administering treatment.

**Correct Answer:** C. Dantrolene