Drug used for intralesional injection of keloid is ?
**Core Concept**
Intralesional injections for keloid management target the reduction of collagen synthesis and the modulation of the inflammatory response. This approach is based on the pathophysiology of keloids, which are characterized by excessive collagen deposition and fibroblast proliferation.
**Why the Correct Answer is Right**
The correct answer is a corticosteroid, specifically triamcinolone acetonide. This medication works by inhibiting the production of pro-inflammatory cytokines, such as IL-1 and IL-6, which are involved in the inflammatory response and collagen synthesis. Triamcinolone acetonide also reduces fibroblast proliferation and collagen production by inhibiting the activity of enzymes like hyaluronic acid synthase and procollagen peptidase. The intralesional injection of triamcinolone acetonide is an effective treatment for keloids due to its ability to modulate the inflammatory response and reduce collagen deposition.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it is not a commonly used medication for intralesional injections in keloid management.
**Option B:** This option is incorrect as it is not a corticosteroid, and therefore does not have the same anti-inflammatory and antifibrotic effects as triamcinolone acetonide.
**Option C:** This option is incorrect as it is not typically used for intralesional injections in keloid management.
**Clinical Pearl / High-Yield Fact**
Intralesional injections of triamcinolone acetonide are most effective when administered early in the course of keloid treatment, as this can prevent further collagen deposition and reduce the risk of recurrence.
**Correct Answer:** C. Triamcinolone acetonide.