Drug that leads to glucose intolerance:
**Core Concept**
Glucose intolerance is a condition characterized by impaired glucose regulation, often resulting from insulin resistance or decreased insulin secretion. This condition can be caused by various factors, including certain medications.
**Why the Correct Answer is Right**
The correct answer is a medication that can lead to glucose intolerance by altering insulin sensitivity or glucose metabolism. For instance, certain steroids, such as **corticosteroids**, can increase gluconeogenesis and impair insulin signaling, leading to glucose intolerance. Corticosteroids stimulate the production of glucose in the liver through the activation of **glucose-6-phosphatase** and inhibit the uptake of glucose by cells through reduced insulin sensitivity.
**Why Each Wrong Option is Incorrect**
**Option A:** Not a commonly recognized cause of glucose intolerance.
**Option B:** Actually used to treat diabetes mellitus, not cause it.
**Option C:** May have various side effects, but glucose intolerance is not a primary concern.
**Clinical Pearl / High-Yield Fact**
When prescribing medications, especially corticosteroids, it's essential to monitor blood glucose levels in patients with a history of diabetes or those at risk of developing glucose intolerance.
**Correct Answer:** C.