Drug of choice in Obsessive compulsive disorder is –
**Core Concept**
The management of Obsessive-Compulsive Disorder (OCD) involves the use of pharmacological agents that modulate neurotransmitter systems, particularly serotonin. Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatment option due to their efficacy and favorable side-effect profile.
**Why the Correct Answer is Right**
The correct answer is an SSRI, specifically Fluoxetine (a selective serotonin reuptake inhibitor). Fluoxetine increases the concentration of serotonin in the synaptic cleft by reducing the reuptake of serotonin into the presynaptic neuron, thereby enhancing serotonergic transmission. This leads to a decrease in the symptoms of OCD, such as obsessions and compulsions.
**Why Each Wrong Option is Incorrect**
**Option A:** Clomipramine (a tricyclic antidepressant) is a serotonin reuptake inhibitor but is not the first-line treatment due to its side-effect profile and the availability of safer alternatives like SSRIs.
**Option B:** Haloperidol (a typical antipsychotic) is not indicated for OCD as it is more likely to worsen symptoms or cause extrapyramidal side effects.
**Option C:** Lithium (a mood stabilizer) is not used in the treatment of OCD; it is primarily used in the management of bipolar disorder.
**Clinical Pearl / High-Yield Fact**
SSRIs are effective in treating OCD, and their efficacy is often seen within 4-6 weeks of treatment initiation.
**Correct Answer: C. Fluoxetine**