**Core Concept**
The management of depression in the elderly population requires careful consideration of the potential side effects and interactions of antidepressant medications. **Selective serotonin reuptake inhibitors (SSRIs)** are often preferred due to their relatively favorable side effect profile.

**Why the Correct Answer is Right**
SSRIs are considered the drug of choice for depression in older adults because they are generally well-tolerated and have a lower risk of adverse effects compared to other antidepressants, such as tricyclic antidepressants (TCAs) or monoamine oxidase inhibitors (MAOIs).

**Why Each Wrong Option is Incorrect**
**Option A:** TCAs can have significant anticholinergic side effects, which may exacerbate cognitive impairment and increase the risk of falls in older adults.
**Option B:** MAOIs can interact with various medications and foods, posing a risk of hypertensive crises.
**Option D:** While other options may be considered, they are not typically the first-line treatment for depression in older adults.

**Clinical Pearl / High-Yield Fact**
It's crucial to start with a low dose and gradually increase as needed and tolerated, due to the potential for increased sensitivity to side effects in the elderly population.

**Correct Answer:** C. SSRI