Drug of choice for pheochromocytoma –
Correct Answer: Phenoxybenzamine
Description: Ans. is 'b' i.e., Phenoxybenzamine Pharmacological treatment of pheochromocvtomao Preoperatively or when tumour cannot be removed, blood pressure control is achieved by cc-adrenoreceptor blockade which reverses peripheral vasoconstriction -Phenoxybenzomine is the DOCo For hypertensive crises or intraoperative control of BP, phentolamine is the DOC. Prazosin is an alternative. Nitroprusside can also be used------Harrison 17th/e p. 1561.o In adrenaline secreting tumors, if tachycardia persists, p-blocker can be added after starting a-blockers.o ACE inhibitor or calcium channel blockers can be used when blood pressure is difficult to control with phenoxybenzamine alone.o Metyrosine has been used with some success to block catecholamine synthesis in malignant pheochromocytoma.o Metaiodobenzylguanidine (MIBG) is actively taken up by adrenergic tissue -123I-MIBG can be used for selective therapeutic irradiation of functioning metastasis.
Category:
Pharmacology
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