**Core Concept**
Dermatitis herpetiformis is a chronic skin condition characterized by intensely itchy blisters, often associated with celiac disease and gluten sensitivity. The treatment of choice aims to manage symptoms and address the underlying gluten intolerance.

**Why the Correct Answer is Right**
The drug of choice for dermatitis herpetiformis is a dapsone, an antibacterial medication that also has anti-inflammatory properties. Dapsone works by inhibiting the production of neutrophil elastase, a key enzyme involved in the inflammatory process. By reducing neutrophil activation, dapsone helps alleviate the symptoms of dermatitis herpetiformis. Additionally, dapsone has been shown to improve the intestinal absorption of nutrients in patients with celiac disease.

**Why Each Wrong Option is Incorrect**
* **Option A:** Corticosteroids, such as prednisone, may be used as a short-term treatment for dermatitis herpetiformis but are not the preferred long-term management option due to potential side effects.
* **Option B:** Topical treatments, such as creams or ointments, may provide temporary relief but do not address the underlying gluten intolerance and are not considered a primary treatment.
* **Option C:** Antihistamines may help alleviate itching but do not treat the underlying cause of dermatitis herpetiformis.

**Clinical Pearl / High-Yield Fact**
It's essential to note that patients with dermatitis herpetiformis often have undiagnosed celiac disease, and treatment with dapsone should be accompanied by a gluten-free diet to manage symptoms effectively.

**Correct Answer: D. Dapsone**