Drug not used in CMV retinitis:
Correct Answer: Acyclovir
Description: Ref: Goodman & Gillman's 13th ed. P 1106-7* Acyclovir's clinical use is limited to herpes viruses. Acyclovir is most active against HSV-1.* Approximately half as active against HSV-2, and a tenth as potent against VZV and EBV.* Book states: "Acyclovir is ineffective therapeutically in established CMV infections, but ganciclovir is effective for CMV prophylaxis in immunocompromised patients* EBV-related oral hairy leukoplakia may improve with acyclovir.* Drugs which can be used in treatment of CMV retinitis are cidofovir, ganciclovir, foscarnet, valaciclovir.* DOC for CMV retinitis: Ganciclovir* Fomivirsen is active against CMV strains resistant to ganciclovir, foscarnet, and cidofovir. Fomivirsen is given by intravitreal injection unresponsive to other therapies.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now