## **Core Concept**
G6PD (Glucose-6-phosphate dehydrogenase) deficiency is a condition where the enzyme G6PD, which protects red blood cells from oxidative damage, is deficient. Certain drugs can trigger hemolysis in individuals with this deficiency by inducing oxidative stress.

## **Why the Correct Answer is Right**
is an antimalarial drug that is generally considered safe in G6PD deficiency. Unlike other antimalarials such as primaquine, which is known to cause hemolysis in G6PD deficient individuals, does not significantly induce oxidative stress in red blood cells.

## **Why Each Wrong Option is Incorrect**
* **Option A:** is known to cause hemolysis in G6PD deficient patients. It induces oxidative stress, which the deficient red blood cells cannot handle.
* **Option B:** can also precipitate hemolysis in individuals with G6PD deficiency for similar reasons of inducing oxidative stress.
* **Option D:** is another drug that can cause hemolysis in G6PD deficiency.

## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is to always screen for G6PD deficiency in patients, especially if they are from high-risk populations (e.g., Mediterranean, African, or Southeast Asian descent), before prescribing drugs known to precipitate hemolysis.

## **Correct Answer:** .