**Question:** Drugs indicated in drug induced vomiting are all except: March 2012

**Core Concept:** Drug-induced vomiting is a side effect caused by certain medications. Understanding the correct treatment options is essential for managing patients who experience this adverse reaction.

**Why the Correct Answer is Right:** The correct answer (D) is chosen because the other options are drugs typically prescribed to counteract vomiting, not exacerbate it. These drugs help in treating the underlying cause of vomiting or provide symptomatic relief.

**Why Each Wrong Option is Incorrect:**

A. Ondansetron (Zofran): This is a selective serotonin receptor antagonist used in the management of nausea and vomiting, particularly in cancer chemotherapy-induced vomiting.

B. Metoclopramide (Reglan): Metoclopramide is a dopamine D2 receptor antagonist and a neuroleptic used for treating nausea and vomiting, including postoperative nausea and vomiting, and in the prevention of migraine attacks.

C. Domperidone (Motilium): Domperidone is a dopamine D2 receptor antagonist and motility agent used to treat nausea, vomiting, and gastrointestinal motility disorders.

D. This option is correct as it highlights that drugs indicated in drug-induced vomiting should not be used, as they either exacerbate vomiting or have no indication in this context.

**Clinical Pearl:** In managing drug-induced vomiting, it is essential to understand the mechanism of action of various drugs and their potential side effects. Always consider the specific cause of vomiting and the appropriate treatment options based on the underlying pathology.

**Correct Answer:** D. This option is correct as it highlights that drugs indicated in drug-induced vomiting should not be used, as they either exacerbate vomiting or have no indication in this context.