**Core Concept**
Drug-induced lupus is a variant of lupus erythematosus that is caused by certain medications, often presenting with **autoantibodies** and **inflammatory** symptoms. The underlying principle involves the **immunological** response triggered by these drugs. This condition is distinct from systemic lupus erythematosus in its **pathophysiology**.

**Why the Correct Answer is Right**
The correct answer is related to the specific characteristics of drug-induced lupus, such as the presence of **antihistone antibodies**, which are more commonly found in this condition than in systemic lupus erythematosus. The mechanism involves the **alteration of immune response** by the offending drug, leading to the production of these antibodies.

**Why Each Wrong Option is Incorrect**
**Option A:** This choice is incorrect because it does not specifically relate to the characteristic **autoantibody profile** seen in drug-induced lupus.
**Option B:** This option is wrong as it is more associated with systemic lupus erythematosus rather than drug-induced lupus.
**Option C:** This choice is incorrect as it is not a distinguishing feature of drug-induced lupus.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that drug-induced lupus often resolves upon **withdrawal of the offending drug**, highlighting the importance of recognizing and managing this condition promptly.

**Correct Answer:** D. Presence of antihistone antibodies.