Drug causing pulmonary eosinophilia are all the following EXCEPT-
**Core Concept**
Pulmonary eosinophilia is a condition characterized by an accumulation of eosinophils in the lungs, often in response to certain medications or infections. This condition can lead to symptoms such as respiratory distress, cough, and chest pain. In the context of drug-induced pulmonary eosinophilia, it is essential to identify the medications that can cause this reaction.
**Why the Correct Answer is Right**
Drug-induced pulmonary eosinophilia is a rare but serious condition that can be caused by various medications. The exact mechanism of this reaction is not fully understood, but it is thought to involve an immune-mediated response to the drug, leading to the activation of eosinophils and their accumulation in the lungs. Certain medications, such as antibiotics (e.g., sulfonamides, nitrofurantoin), anticonvulsants (e.g., carbamazepine, phenytoin), and NSAIDs, have been associated with this condition.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a known cause of pulmonary eosinophilia. The medication listed can induce an immune-mediated response, leading to the accumulation of eosinophils in the lungs.
**Option B:** This option is incorrect because it is a known cause of pulmonary eosinophilia. The medication listed can cause a hypersensitivity reaction, leading to the activation of eosinophils and their accumulation in the lungs.
**Option C:** This option is incorrect because it is a known cause of pulmonary eosinophilia. The medication listed can induce an immune-mediated response, leading to the accumulation of eosinophils in the lungs.
**Option D:** This option is correct because it is not a known cause of pulmonary eosinophilia. The medication listed is not typically associated with this condition, and it is not a common cause of hypersensitivity reactions or immune-mediated responses.
**Clinical Pearl / High-Yield Fact**
When considering a diagnosis of drug-induced pulmonary eosinophilia, it is essential to take a thorough medication history and to consider medications that are known to cause this reaction. The condition can be challenging to diagnose, and a high index of suspicion is necessary to identify patients at risk.
**Correct Answer:** D.