Down’s syndrome most commonly occurs due to –
Correct Answer: Nondysjunction in maternal meiosis
Description: In trisomy 21, the additional number 21 chromosome is derived from the mother in 95% of cases.
It is due to nondisjunction of the 21st chromosome at the time of meiosis.
In nondisjunction, chromosomal pair fails to separate in the first meiotic division during gametogenesis.
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