**Question:** Down Syndrome, all are seen except

A. Short stature
B. Hypertrophic cardiomyopathy
C. Hypothyroidism
D. Colon cancer

**Core Concept:** Down syndrome is a genetic disorder caused by the presence of an extra copy of chromosome 21. This leads to various developmental and physiological abnormalities.

**Why the Correct Answer is Right:** In Down syndrome, the presence of an extra chromosome 21 disrupts normal development, leading to characteristic features. Short stature is a result of developmental abnormalities associated with Down syndrome, but the other options are less common or not directly linked to having an extra chromosome 21.

**Why Each Wrong Option is Incorrect:**

B. Hypertrophic cardiomyopathy: Though some cardiac abnormalities are seen in Down syndrome, hypertrophic cardiomyopathy is not a typical finding. It is a specific heart condition characterized by an abnormal thickening of the heart muscle, which is not directly linked to having an extra chromosome 21.

C. Hypothyroidism: Hypothyroidism is a condition caused by an underactive thyroid gland. Down syndrome is not directly linked to hypothyroidism, so this option is incorrect.

D. Colon cancer: Colon cancer is a type of cancer that develops in the large intestine. In Down syndrome, there is an increased risk of certain cancers, including leukemia and lymphoma, but colon cancer is not a typical feature of the condition.

**Clinical Pearl:** Down syndrome is associated with an increased risk of certain cancers, particularly leukemia and lymphoma. However, the presence of an extra chromosome 21 does not directly lead to colon cancer, making this option incorrect.

**Correct Answer:** D. Colon cancer: While Down syndrome is associated with an increased risk of certain cancers, colon cancer is not a typical feature of the condition.