**Core Concept**
Streptokinase is a thrombolytic agent used to dissolve fibrin clots in acute myocardial infarction (MI). It works by activating plasminogen to plasmin, which then breaks down fibrin into soluble products.
**Why the Correct Answer is Right**
The recommended dose of streptokinase for fibrinolysis in MI is typically 1.5 million units administered over 30-60 minutes. This dose is chosen to achieve a balance between efficacy and safety, as higher doses can increase the risk of bleeding complications. The administration of streptokinase is usually followed by a bolus of heparin to prevent further clot formation and maintain patency of the coronary arteries.
**Why Each Wrong Option is Incorrect**
* **Option A:** This dose is too low and may not be effective in dissolving the fibrin clot, potentially resulting in worsening of the MI.
* **Option B:** This dose is too high and may increase the risk of bleeding complications, such as hemorrhagic stroke or gastrointestinal bleeding.
* **Option C:** This option is not a valid dose of streptokinase for fibrinolysis in MI, and may be a distractor to test the student's knowledge of the correct dose.
**Clinical Pearl / High-Yield Fact**
When administering streptokinase for fibrinolysis in MI, it is essential to monitor the patient closely for signs of bleeding and to have a plan in place for managing potential bleeding complications.
**Correct Answer: B. 750,000 units over 30 minutes**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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