Dose of rifampicin in RNTCP is-
**Core Concept**
The **Revised National Tuberculosis Control Programme (RNTCP)** in India utilizes a standardized treatment regimen for tuberculosis, which includes **rifampicin**, a key **antitubercular drug**. Rifampicin works by inhibiting **RNA synthesis** in Mycobacterium tuberculosis.
**Why the Correct Answer is Right**
The correct dose of rifampicin in RNTCP is based on the patient's weight, but a common dose used is 450 mg for adults, given the importance of **rifampicin** in the treatment regimen due to its potent **bactericidal activity**. This dose is crucial for effectively treating tuberculosis while minimizing the risk of **drug resistance**.
**Why Each Wrong Option is Incorrect**
**Option A:** This dose is incorrect as it does not align with the standard RNTCP guidelines.
**Option B:** Similarly, this option does not reflect the recommended dosage.
**Option D:** This is also an incorrect dose, not matching the RNTCP protocol.
**Clinical Pearl / High-Yield Fact**
Remember, **rifampicin** is a critical component of tuberculosis treatment due to its ability to kill **Mycobacterium tuberculosis** effectively, and its dose must be carefully managed to prevent **resistance** and ensure **treatment efficacy**.
**Correct Answer:** C. 450 mg