Ans. is 'b' i.e., 450 mg TREATMENT REGIMEN SPUTUM EXAMINATIONS FOR PULMON ARY TBCategory of treatmentType of patientRegimentPre treatment sputumTest at monthIf result isTHEN -Start continuation phase, test sputum 6 monthsNew casesNew sputum smear-positive2(HRZE)3+-2 Category 1New sputum semar-negative+ +Continue intesive phase for one more montfRed BoxNew extra-pulmonaryNew others4 (HR)3 Complete the treatment in 7 monthsPreviouslySputum smear-positive Relapse2(HRZES}3 -Start continuation phase, test sputum again 6 months, completion of treatmentTreatedSputum smear-positive Fa ilure+ Category IISputum smear-positive1 (HRZE)3+3+Continue intensive phase for one more monthBlue Boxtreatment after default Others+5 (HRE)3 again at 4 months if sputum is positive sene sputum for culture and drug sensitivity as might be a case of MDR-TBo The number before the letters refers to the number of months of treatment. The subscript after the letters refers to the number of doses per week- H : Isomazid (600 mg), R : Rifampicin (450 mg), Z : Pyrazinamide (1500 mg), E : Ethambuiol (1200 mg), S : Streptomycin (750 mg). Patients who weight more than 60 kg receive additional Rifampicin 150 mg. Patients more than 50 years old receive streptomycin 500 mg- Patient in categories I and 11, Who have a positive sputum smear at the end of the initial intensive phase, receive an additional month of intensive phase treatment.o Examples of seriously ill extra-pulmonary TB cases are meningitis, disseminated TB, tuberculous pericarditis, peritonitis, bilateral or extensive pleurisy, spinal TB with neurological complications and intestinal and genito-urinary TB.o In rare and exeptional cases, patients who are sputum smear-negative or who have extra-pulmonary disease can have relapse or failure. This diagnosis in all such cases should always be made by an MO and should be supported by culture or histological evidence of current, active tuberculosis. In these cases, the patient should be categorized as 'other' and given category II treatment.o Any patient treated writb category I who has a positive smear at 5 months of treatment should be considered a Failure and started on category II treatment, afresh. If category I sputum smear-ve case fails to improve or if patient develops pulmonary signs and positive smear at the end of intensive phase, it is considered treatment failure. Start category II treatment and confirm failure by culture and perform DST.