**Core Concept**
Dermatitis herpetiformis is a chronic skin condition characterized by intensely itchy, blistering skin lesions. It is associated with gluten sensitivity and is often seen in patients with celiac disease. The pathophysiology involves an immune-mediated reaction to gluten, leading to the deposition of IgA antibodies in the skin.

**Why the Correct Answer is Right**
The treatment of choice for dermatitis herpetiformis involves a strict gluten-free diet, which helps to alleviate symptoms and prevent complications. Dapsone is a commonly used medication to manage the symptoms of dermatitis herpetiformis, particularly the itching and blistering. It works by inhibiting the production of leukotrienes, which are chemical mediators involved in the inflammatory response.

**Why Each Wrong Option is Incorrect**
**Option A:** Corticosteroids, such as prednisone, may provide temporary relief from symptoms but are not a long-term solution and can have significant side effects. They do not address the underlying gluten sensitivity.
**Option B:** Topical antibiotics are not effective in treating dermatitis herpetiformis, as the condition is caused by an immune-mediated reaction rather than a bacterial infection.
**Option C:** Antihistamines may provide relief from itching but do not address the underlying cause of the condition.

**Clinical Pearl / High-Yield Fact**
Dermatitis herpetiformis is often associated with other autoimmune conditions, such as celiac disease, type 1 diabetes, and thyroid disease. A gluten-free diet is essential for managing the condition and preventing long-term complications.

**Correct Answer: D. Dapsone.**