DOC for acute organophosphate poisoning is:
Correct Answer: Atropine
Description: Atropine
It is highly effective in counteracting the muscarinic symptoms, but higher doses are required to antagonize the central effects. It does not reverse peripheral muscular paralysis which is a nicotinic action.
All cases of anti-ChE (carbamate or organophosphate) poisoning must be promptly given atropine 2 mg i.v. repeated every 10 min till dryness of mouth or other signs of atropinization appear (upto 200 mg has been administered in a day). Continued treatment with maintenance doses may be required for 1- 2 weeks.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 122,123
Category:
Pharmacology
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