**Core Concept**
Disulfiram is a medication used in the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). This is achieved through a disulfiram-ethanol reaction, which leads to the accumulation of acetaldehyde, a toxic metabolite of ethanol. The disulfiram-ethanol reaction is characterized by symptoms such as flushing, nausea, vomiting, and palpitations.
**Why the Correct Answer is Right**
The disulfiram-like reaction with alcohol is seen with certain medications that inhibit aldehyde dehydrogenase, the enzyme responsible for converting acetaldehyde to acetic acid. One such medication is metronidazole, an antibiotic used to treat infections caused by anaerobic bacteria and protozoa. When metronidazole is taken with alcohol, it leads to the accumulation of acetaldehyde, resulting in a disulfiram-like reaction.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify a medication that causes a disulfiram-like reaction with alcohol.
**Option B:** This option is incorrect because it does not mention a medication that inhibits aldehyde dehydrogenase, the enzyme responsible for the disulfiram-like reaction.
**Option C:** This option is incorrect because it is not a medication that causes a disulfiram-like reaction with alcohol.
**Clinical Pearl / High-Yield Fact**
Metronidazole and other medications that inhibit aldehyde dehydrogenase can cause a disulfiram-like reaction with alcohol, leading to symptoms such as flushing and nausea. This reaction can be used as a diagnostic tool to identify patients who are taking these medications.
**Correct Answer:** C.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.