**Core Concept**
Neonatal seizures are a significant concern in the neonatal period, and their prognosis varies depending on the underlying cause. In some disorders, seizures are associated with a poor prognosis due to underlying brain injury or structural abnormalities.

**Why the Correct Answer is Right**
The correct answer is associated with a better prognosis because it does not typically involve structural brain abnormalities or significant brain injury. In contrast, disorders like congenital infections, stroke, and hypoxic-ischemic encephalopathy are associated with a poor prognosis. These conditions can lead to long-term neurodevelopmental sequelae and may result in significant morbidity.

**Why Each Wrong Option is Incorrect**
* **Option A:** Congenital infections, such as toxoplasmosis or cytomegalovirus, are known to cause significant brain injury and are associated with a poor prognosis in neonates with seizures.
* **Option B:** Stroke in the neonatal period is a medical emergency and is often associated with significant brain injury, resulting in a poor prognosis.
* **Option D:** Hypoxic-ischemic encephalopathy is a leading cause of neonatal seizures and is associated with a poor prognosis due to the potential for long-term neurodevelopmental sequelae.

**Clinical Pearl / High-Yield Fact**
Neonatal seizures should be evaluated promptly, and underlying causes should be identified to guide management and improve outcomes. A thorough evaluation, including imaging and laboratory studies, is essential to determine the cause of seizures and develop an appropriate treatment plan.

**Correct Answer: D. Hypoxic-ischemic encephalopathy is associated with a poor prognosis in neonates with seizures.**