**Core Concept**
Autosomal recessive disorders are inherited in a pattern where a person must inherit two copies of a mutated gene (one from each parent) to express the condition. Carriers, who have one mutated gene, typically do not show symptoms but can pass the mutation to their offspring.
**Why the Correct Answer is Right**
The disorders listed are inherited in autosomal recessive mode, which means they require two copies of a mutated gene to manifest. This mode of inheritance is characterized by the following features: 1) the disorder does not skip generations, 2) carriers (heterozygotes) are typically asymptomatic, and 3) the risk of transmission to offspring is 25% for each child. The correct answer will be the disorder that does not follow this pattern.
**Why Each Wrong Option is Incorrect**
* **Option A:** This disorder is inherited in an autosomal dominant pattern, where a person only needs to inherit one copy of the mutated gene to express the condition. This makes it the correct answer.
* **Option B:** This disorder is indeed inherited in an autosomal recessive mode, requiring two copies of the mutated gene to manifest.
* **Option C:** This disorder is also inherited in an autosomal recessive mode, following the characteristic features of this pattern.
* **Option D:** This disorder is inherited in an autosomal recessive mode, requiring two copies of the mutated gene to express the condition.
**Clinical Pearl / High-Yield Fact**
When evaluating a patient's family history for genetic disorders, it is essential to understand the mode of inheritance to provide accurate genetic counseling and predict the risk of transmission to offspring.
**Correct Answer: A. This disorder is inherited in an autosomal dominant pattern.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.