Diseases which show presence of fibrinoid necrosis are all except ?
**Core Concept**
Fibrinoid necrosis is a type of coagulative necrosis characterized by the deposition of fibrin-like proteinaceous material in the arterial walls, often associated with severe hypertension, autoimmune diseases, and certain types of vasculitis. This pathological process involves the disruption of the normal architecture of the arterial wall, leading to vascular damage and potential organ dysfunction.
**Why the Correct Answer is Right**
The presence of fibrinoid necrosis is a hallmark of conditions such as malignant hypertension, polyarteritis nodosa, and systemic lupus erythematosus. In these diseases, the inflammatory response and immune complex deposition lead to the activation of various enzymes, including plasminogen activator, which causes the breakdown of the arterial wall and the subsequent deposition of fibrin-like material. This process is often accompanied by the infiltration of inflammatory cells and the release of vasoactive substances, which can exacerbate vascular damage.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because while it may be a type of vasculitis, it does not typically show fibrinoid necrosis. Instead, it is characterized by the presence of granulomas and a more chronic inflammatory response.
**Option B:** This option is incorrect because it is a type of vasculitis that primarily affects the small vessels and is characterized by the presence of granulomas and a more chronic inflammatory response, rather than fibrinoid necrosis.
**Option C:** This option is incorrect because it is a type of autoimmune disease that primarily affects the joints and is characterized by the presence of rheumatoid factor and a specific pattern of inflammatory cell infiltration, rather than fibrinoid necrosis.
**Clinical Pearl / High-Yield Fact**
Fibrinoid necrosis is often associated with severe hypertension, which can cause damage to the arterial walls and lead to the deposition of fibrin-like material. This can have significant implications for patient management, as controlling blood pressure is crucial in preventing further vascular damage.
**Correct Answer:**
. Wegener's granulomatosis