## **Core Concept**
DNA replication is a semi-conservative process where the genetic material is duplicated. In this process, DNA synthesis occurs in a discontinuous manner on the lagging strand due to the antiparallel nature of DNA and the unidirectional activity of DNA polymerase.

## **Why the Correct Answer is Right**
The correct answer, **Okazaki fragments**, refers to the short, discontinuous segments of DNA that are synthesized on the lagging strand during DNA replication. This occurs because DNA polymerase can only synthesize DNA in one direction, and the lagging strand template runs in the opposite direction to the overall replication fork movement. As a result, DNA synthesis on the lagging strand is initiated in short, discontinuous segments.

## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is blank and does not provide a viable alternative.
- **Option B:** This option is also blank and does not offer a correct term related to DNA replication.
- **Option C:** Similarly, this option does not provide a relevant term.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that Okazaki fragments are essential for the replication of the lagging strand. These fragments are later joined together by DNA ligase to form a continuous strand. This process highlights the complex and highly regulated nature of DNA replication.

## **Correct Answer:** D. Okazaki fragments