A patient’s urine with a particular protein appears normal, but on standing it becomes dark. The dark colour disappears on heating. The patient is suffering from
## **Core Concept**
The question describes a scenario where a patient's urine appears normal initially but turns dark upon standing. This characteristic change in urine color is indicative of a specific condition related to a protein in the urine. The key concept here involves understanding the properties of different proteins and their behavior in urine under various conditions.
## **Why the Correct Answer is Right**
The correct answer, **B. Bence Jones protein**, is related to multiple myeloma, a type of blood cancer characterized by the proliferation of malignant plasma cells in the bone marrow. Bence Jones proteins are light chains of immunoglobulins (antibodies) that are produced by these malignant plasma cells. These proteins are unique because they can be found in the urine of patients with multiple myeloma. A distinctive feature of Bence Jones proteins is that they coagulate or precipitate when heated to a temperature between 40°C to 60°C but redissolve when heated further. This property explains why the dark color (due to the presence of Bence Jones proteins) disappears on heating.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because it does not specify a condition or protein related to the described phenomenon.
- **Option C:** This option is incorrect as there is no common condition or protein associated with the described urine changes that matches this choice.
- **Option D:** Similarly, this option does not correspond to a known condition or protein that would cause the described changes in urine.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that Bence Jones proteins are associated with multiple myeloma and can cause urine to change color under specific conditions. The heat test is a classic method for detecting Bence Jones proteins, which precipitate with heat but dissolve with boiling. This is a high-yield fact for exams as it combines clinical presentation with a specific diagnostic clue.
## **Correct Answer: B. Bence Jones protein**