**Core Concept:**
Digoxin is a cardiac glycoside used for the management of symptomatic atrial fibrillation, heart failure, and some forms of ventricular arrhythmias. It increases the contractility of cardiac muscle cells by blocking the sodium-potassium ATPase pump, leading to an increase in intracellular sodium concentration and subsequent calcium influx. This results in enhanced contractility and reduced heart rate. However, digoxin can also cause ventricular arrhythmias due to its effects on the sodium-potassium ATPase pump in ventricular myocytes.

**Why the Correct Answer is Right:**
The drug of choice for digoxin-induced ventricular tachyarrhythmias is Class III antiarrhythmic agents (e.g., amiodarone, sotalol, and dofetilide). These agents work by blocking the rapid delayed rectifier potassium current (Ikr) in ventricular myocytes, leading to a decrease in repolarization and an increase in action potential duration. This results in a longer refractory period, reducing the likelihood of re-entry and ventricular arrhythmias.

**Why Each Wrong Option is Incorrect:**
A. Amiodarone is incorrect because it is a broad-spectrum antiarrhythmic agent used for various arrhythmias. It is not specific for digoxin-induced ventricular tachyarrhythmias, and its use may cause significant side effects.
B. Sotalol is incorrect as it is a beta-blocker and class III antiarrhythmic agent. While it is effective in treating ventricular tachyarrhythmias, it is not specifically indicated for digoxin-induced arrhythmias.
C. Dofetilide is incorrect because it is a selective class III antiarrhythmic agent, which blocks Ikr in ventricular myocytes. However, it is not used specifically for digoxin-induced ventricular arrhythmias, and its use can lead to the development of class III antiarrhythmic-related side effects.

**Clinical Pearl:**
In patients with digoxin-induced ventricular tachyarrhythmias, a selective class III antiarrhythmic agent like sotalol or dofetilide is preferable over amiodarone due to its narrow therapeutic index, potential side effects, and lack of specificity for digoxin-induced arrhythmias.

**Correct Answer:**
Dofetilide is the correct answer as it is a selective class III antiarrhythmic agent that blocks Ikr in ventricular myocytes, effectively treating digoxin-induced ventricular arrhythmias without causing the side effects commonly associated with amiodarone.