Digoxin toxicity may result from the concurrent administration of digoxin with all of the following drugs EXCEPT.
**Core Concept**
Digoxin toxicity is a serious condition that can occur when the levels of digoxin, a cardiac glycoside, become too high in the body. This can happen due to various factors, including the concurrent administration of other medications that interact with digoxin.
**Why the Correct Answer is Right**
Digoxin toxicity is often caused by the inhibition of the enzyme P-glycoprotein, which is responsible for the efflux of digoxin from the body. Certain medications can inhibit P-glycoprotein, leading to increased digoxin levels and toxicity. However, not all medications interact with digoxin in this way.
**Why Each Wrong Option is Incorrect**
**Option A:** Quinidine is a medication that can inhibit P-glycoprotein, leading to increased digoxin levels and toxicity. Therefore, it is not the correct answer.
**Option B:** Amiodarone can also inhibit P-glycoprotein, leading to increased digoxin levels and toxicity. So, it is not the correct answer either.
**Option C:** Furosemide is a loop diuretic that can increase digoxin levels by reducing its clearance, but it is not the correct answer because it does not inhibit P-glycoprotein.
**Clinical Pearl / High-Yield Fact**
When prescribing medications that interact with digoxin, it is essential to monitor digoxin levels closely and adjust the dosage accordingly.
**Correct Answer: C. Furosemide**