Digoxin can accumulate to toxic levels in patients with:
Correct Answer: Renal insufficiency
Description: Digoxin is primarily excreted unchanged by the kidney, mainly by glomerular filtration. Rate of excretion is altered parallel to creatinine clearance. Its t½ is prolonged in elderly patients and in those with renal insufficiency: dose has to be reduced.
Digoxin is a cumulative drug. When maintenance doses are given from the beginning, steady state levels and full therapeutic effect are attained after 4 x t½, i.e. 6-7 days.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 560
Category:
Pharmacology
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