Difference between action of DEC and Ivermectin in a case of scrotal filariasis is –
**Core Concept**
Scrotal filariasis is caused by the parasite Wuchereria bancrofti, which leads to lymphatic obstruction and elephantiasis. DEC (Diethylcarbamazine) and Ivermectin are two antifilarial drugs used to treat this condition. The key difference lies in their mechanism of action and efficacy against the adult worms and microfilariae.
**Why the Correct Answer is Right**
DEC acts by releasing a cytotoxic compound, which leads to the death of microfilariae. It also causes the death of adult worms by inducing a hypersensitivity reaction in the host. This reaction leads to the death of the adult worms, but it is not a direct effect on the worms. In contrast, Ivermectin acts by binding to glutamate-gated chloride channels on the worm's nervous system, causing paralysis and death of the microfilariae and adult worms. Ivermectin is more effective against the adult worms than DEC.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided, so we cannot explain why it is incorrect.
* **Option B:** This option is not provided, so we cannot explain why it is incorrect.
* **Option C:** This option is not provided, so we cannot explain why it is incorrect.
* **Option D:** This option is not provided, so we cannot explain why it is incorrect.
**Clinical Pearl / High-Yield Fact**
It is essential to note that DEC is more effective against the microfilariae, while Ivermectin is more effective against the adult worms. This knowledge is crucial when choosing the appropriate treatment for scrotal filariasis.
**Correct Answer: C.**