Diethylstilbesterol causes the following defects except:
**Core Concept**
Diethylstilbestrol (DES) is a synthetic estrogen that was historically used in pregnancy to prevent miscarriage and other complications. However, it has been linked to various congenital anomalies and reproductive issues in offspring exposed in utero.
**Why the Correct Answer is Right**
Diethylstilbestrol is known to cause clear cell adenocarcinoma of the vagina and cervix, as well as other reproductive tract anomalies, in females exposed to it in utero. The mechanism of DES-induced cancer is thought to involve the promotion of abnormal cell growth and differentiation in the reproductive tract. The estrogenic effects of DES can also lead to other developmental abnormalities, such as cryptorchidism and hypospadias in males.
**Why Each Wrong Option is Incorrect**
**Option A:**
* This option is not a known effect of DES exposure.
**Option B:**
* This option is a known effect of DES exposure, as DES can cause clear cell adenocarcinoma of the vagina and cervix in females.
**Option C:**
* This option is a known effect of DES exposure, as DES can cause reproductive tract anomalies, including hypospadias and cryptorchidism, in males.
**Clinical Pearl / High-Yield Fact**
DES exposure in utero has been linked to an increased risk of reproductive tract anomalies and clear cell adenocarcinoma of the vagina and cervix in females.
**Correct Answer:** A.