Diethvlstilbesterol causes the following defects except:
**Core Concept**
Diethylstilbestrol (DES) is a synthetic estrogen that was historically used in pregnancy to prevent miscarriage and premature labor. However, it has been linked to various health problems in individuals exposed in utero.
**Why the Correct Answer is Right**
DES is known to cause clear cell adenocarcinoma of the vagina and cervix in exposed females. This is due to the estrogenic effects of DES on the developing reproductive tract, leading to abnormal cellular differentiation and increased risk of cancer. The exact mechanism involves the disruption of normal embryonic development, particularly in the Müllerian ducts, which give rise to the female reproductive organs.
**Why Each Wrong Option is Incorrect**
**Option A:**
DES is also associated with reproductive tract abnormalities, such as vaginal and cervical abnormalities, and infertility issues in exposed females.
**Option B:**
DES exposure has been linked to an increased risk of testicular cancer in males exposed in utero.
**Option C:**
DES exposure has been linked to an increased risk of breast cancer in females exposed in utero.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that DES exposure can have long-term consequences, even in individuals who do not exhibit immediate symptoms.
**Correct Answer: B. DES is also associated with reproductive tract abnormalities, such as vaginal and cervical abnormalities, and infertility issues in exposed females.**