Dicumarol is a drug that impairs the utilization of vitamin K by the liver. Dicumarol therapy, therefore, would decrease the plasma concentration of which of the following procoagulants?
Correct Answer: Prothrombin
Description: Dicumarol inhibits the action of vitamin K, which is a necessary cofactor for the enzyme that catalyzes the conversion of glutamic acid residues to g-carboxyglutamic acid residues.Six of the proteins involved in clotting require conversion of a number of glutamic acid residues to g-carboxyglutamic acid residues before being released into the circulation, and hence all six are vitamin K-dependent. These proteins include factors II (prothrombin)Others are; factors VII, IX, and X, protein C, and protein S Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No: 535
Category:
Physiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now