**Core Concept**
Dialysis is a treatment used to remove waste products from the blood when the kidneys are not functioning properly. Certain medications can be resistant to dialysis due to their chemical properties, such as high molecular weight, lipophilicity, or binding to plasma proteins.

**Why the Correct Answer is Right**
The correct answer is D. All of the above because all the listed medications have properties that make them resistant to dialysis. Amphetamine (A) is a highly lipophilic compound that can bind to plasma proteins, making it difficult to remove through dialysis. Digoxin (B) has a high molecular weight and is also highly bound to plasma proteins, which limits its removal by dialysis. Propranolol (C) is a lipophilic beta-blocker that is extensively bound to plasma proteins, making it resistant to dialysis. These properties prevent dialysis from effectively removing these medications from the bloodstream.

**Why Each Wrong Option is Incorrect**
**Option A:** Amphetamine is not entirely resistant to dialysis, and some degree of removal can occur, although it is limited due to its lipophilicity and protein binding.

**Option B:** Digoxin can be removed to some extent through dialysis, although its high molecular weight and protein binding limit its removal efficiency.

**Option C:** Propranolol can also be removed to some extent through dialysis, although its lipophilicity and protein binding make it resistant to dialysis.

**Clinical Pearl / High-Yield Fact**
When managing patients on dialysis, it's essential to consider the pharmacokinetics of medications and their potential resistance to dialysis to avoid under- or over-dosing. This can be achieved by using alternative treatment strategies, such as adjusting medication dosages or switching to medications that are more easily removed by dialysis.

**Correct Answer:**
✓ Correct Answer: D. All of the above