Diagnostic investigation of Multiple myeloma:
Correct Answer: Serum electrophoresis
Description: Ans: d (S. electrophoresis) Ref: Harrison, 16th p. Davidson, 20th ed, p. 1052Confused? Option D is definitely better than option A. Eventhough both lytic bone lesions and S. electrophoresis are included in the diagnostic criteria, according to the diagnostic criteria defined by Salmon & Durie, only monoclonal globulin spikes on S. electrophoresis is taken as major criteria. Lytic bone lesion is taken as a minor criteria only.Diagnosis of multiple myeloma (The durie and salmon myeloma diagnostic criteria).The diagnosis of multiple myeloma requires a minimum of one major and one minor criteria or three minor criteria as defined in the Table below.Major criteria1) Plasmacytoma on tissue biopsy2) Bone marrow palsmacytosis with 30% plasma cells3) Monoclonal globulin spike (M protein) on SPEP: IgG>3.5g/dl, IgA > 2.0g/dl. light chain excretion in UPEP > 1 g per 24 hr in the absence of amylodosis.Minor criteria1) Bone marrow plasmacytosis with 10-30% plasma cells2) Monclonal globulin spike present, but lower levels than defined in major criteria3) Lytic bone lesions4) Normal IgM >50 mg/dl. IgA > 100 mg/dl, or IgG >600 mg/dlThe diagnosis of myeloma requires a minimum of one major criteria and one minor criteria (although 1 +a is not sufficient) or three minor criteria that must include a+b.(SPEP-serum protein electrophoresis. UPEP--urine protein electrophoresis)
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now